Calcium Hydroxyapatite

Determination of the Ca/P Molar Ratio in Calcium Hydroxyapatite

Hydroxyapatite (HA), Ca10(PO4)6(OH)2 is an important biomaterial, as it is able to bond chemically to bone. In clinical applications of dental reconstruction and hip replacement, hydroxyapatite has found wide and accepted use as a source material for plasma sprayed, bonelike coatings deposited onto metallic substrates.

With the advent of mass production of hydroxyapatite-coated devices, reliable measures have to be implemented to assure their chemical integrity. One important and strongly regulated quality indicator of HA is its Ca/P molar ratio. A successful and  precise method for the determination of the molar Ca/P ratio in hydroxyapatite is X-ray spectroscopy (XRF). This method, especially in combination with the determination of the crystalline/amorphous ratio of HA by X-ray diffraction method (XRD), provides a suitable procedure for the reliable quality control of hydroxyapatite.


CAMET Research, Inc.
An X-Ray Diffraction (XRD) Laboratory
6409 Camino Vista #F, Goleta, CA 93117, USA
Phone: (805) 685-1665
Fax: (805) 685-9082